Sequential transcriptional programs underpin activation of hippocampal stem cells.

Piero Rigo, Sara Ahmed-de-Prado, Rebecca L Johnston, Chandra Choudhury, François Guillemot, Lachlan Harris

Neural Stem Cell Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.Neural Stem Cell Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK. · pubmed

Paper

Abstract

Adult neural stem cells exist on a continuum from deep to shallow quiescence that changes in response to injury or aging; however, the transcription factors controlling these stepwise transitions have not been identified. Single-cell transcriptomic analyses of mice with loss of function or increased levels of the essential activation factor

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims to identify transcription factors that control the activation of hippocampal stem cells in response to aging and injury. This research is relevant as it explores the mechanisms underlying neural stem cell activation, which could contribute to understanding and potentially mitigating age-related decline in cognitive function.

Author of this paper? Send a correction.