Metabolomics-Based Identification and Validation of the Creatine Precursor Guanidinoacetic Acid for Frailty in Older Adults.

Yin Yuan, Xiaoming Huang, Siyang Lin, Wenwen Lin, Feng Huang, Pengli Zhu

Shengli Clinical Medical College, Fujian Medical University, Fuzhou, China.Shengli Clinical Medical College, Fujian Medical University, Fuzhou, China. · pubmed

Paper

Abstract

Subtle biological changes related to frailty may be undetected by standard clinical methods, and reliable biomarkers for frailty are still under investigation. This study was conducted to profile plasma metabolite patterns associated with frailty and validate the most significant metabolite for identifying and predicting frailty in cross-sectional and longitudinal analyses.

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Research summary

The paper identifies and validates guanidinoacetic acid as a metabolite associated with frailty in older adults. This research is relevant as it seeks to uncover biomarkers that could help in understanding and potentially mitigating frailty, which is a significant aspect of aging and longevity.

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