Sex alters thyroid hormone's effect on protein O-GlcNAcylation in the aged mouse heart.

Aaron K Olson, Wei Zhong Zhu, Dolena Ledee

Norcliffe Foundation Center for Integrative Brain Research, Seattle Children's Research Institute, 1900 9th Ave., Seattle, Washington, USA.Norcliffe Foundation Center for Integrative Brain Research, Seattle Children's Research Institute, 1900 9th Ave., Seattle, Washington, USA. · pubmed

Paper

Abstract

The aging heart undergoes physiological changes, many of which are sex dependent and encompass differential responses to cardiac stress. However, much about the molecular changes that occur within the aging heart is still unknown. Thyroid hormone (TH) and the posttranslational modification O-GlcNAcylation (O-GlcNAc) are independently known to regulate cardiac function; therefore, we tested the hypothesis that TH disorders affect cardiac protein O-GlcNAcylation in aged hearts.

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Research summary

The paper claims that thyroid hormone disorders affect cardiac protein O-GlcNAcylation in aged hearts. This research is relevant as it explores molecular changes in the aging heart, which could contribute to understanding the underlying mechanisms of aging and age-related cardiac dysfunction.

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