Protection against APOE4-associated phenotypes with the longevity-promoting intervention 17α-estradiol in middle-aged male mice.

Cassandra J McGill, Amy Christensen, Wenjie Qian, Max A Thorwald, Jose Godoy Lugo, Sara Namvari, Olivia S White, Caleb E Finch, Bérénice A Benayoun, Christian J Pike

Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA. · pubmed

Paper

Abstract

The apolipoprotein ε4 allele (APOE4) is associated with decreased longevity and increased vulnerability to age-related declines and disorders across multiple systems. Interventions that promote healthspan and lifespan represent a promising strategy to attenuate the development of APOE4-associated aging phenotypes. Here, we studied the ability of the longevity-promoting intervention 17α-estradiol (17αE2) to protect against impairments in APOE4 versus the predominant APOE3 genotype using early middle-aged mice with knock-in of human APOE alleles.

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Research summary

The paper claims that 17α-estradiol can protect against aging-related impairments associated with the APOE4 genotype in middle-aged mice. This research is relevant as it explores a potential intervention that targets the underlying mechanisms of aging and longevity, specifically in the context of a genetic risk factor for age-related decline.

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