The n-butanol extract of Polygonatum sibiricum improves spleen aging via p53 pathway.

Jingtong Chao, Yu Wang, Qidi Huang, Huiwen Zhang, Yigong Chen, Xiamei Cheng, Jiayin Mao, Jingjing Yu, Meiqiu Yan, Suhong Chen, Guiyuan Lv, Jie Su

School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China. · pubmed

Paper

Abstract

Aging affects the function of multiple organs, including the spleen, which undergoes age-related structural changes and functional decline. Polygonatum sibiricum, a traditional anti-aging herbal medicine, contains saponins as its primary active components. However, the potential effects and underlying mechanisms of Polygonatum n-butanol extract (PNBE), which is rich in saponins, on splenic aging remain to be elucidated.

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Research summary

The n-butanol extract of Polygonatum sibiricum improves spleen aging via the p53 pathway. This study investigates a potential intervention targeting the aging process in the spleen, which aligns with the goal of addressing the root causes of aging rather than merely treating age-related symptoms.

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