Potential Probiotic Lacticaseibacillus rhamnosus NKU FL1-11 Prevents Aging-Related Oxidative Stress and Inflammation via mTOR and FoxO Signaling Pathways in Zebrafish.
Abstract
Aging, a complex physiological process characterized by multi-organ involvement and closely associated with oxidative stress and chronic inflammation, has prompted growing scientific interest in natural antioxidant probiotics due to their dual health-promoting properties and anti-oxidative capabilities. However, the effectiveness and mechanisms of multiple emerging Lacticaseibacillus rhamnosus (L. rhamnosus) strains extracted from the fecal microbiota of breastfed infants on zebrafish models remain unclear. In this study, the anti-aging potential of L. rhamnosus NKU FL1-11, selected for its potent inhibition of senescence-associated β-galactosidase activity, was systematically investigated using H
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Research summary
The paper claims that Lacticaseibacillus rhamnosus NKU FL1-11 can prevent aging-related oxidative stress and inflammation through specific signaling pathways in zebrafish. This research is relevant as it explores a potential intervention targeting the biological mechanisms of aging, specifically oxidative stress and inflammation, which are key contributors to the aging process.
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