Associations of serum Klotho with diabetic kidney disease prevalence and mortality: insights from a nationally representative U.S. cohort.

Peichen Xie, Dingding Wang, Meng Zhang, Lanping Jiang, Yagui Qiu, Yiqin Wang, Siyang Ye, Manhuai Zhang, Li Tan, Sixiu Chen, Qianling Liu, Huajing Peng, Suchun Li, Jianbo Li, Qiong Wen, Leigang Jin, Xiaoping Wu, Kam Wa Chan, Sydney C W Tang, Wei Chen, Bin Li

Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China.Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China. · pubmed

Paper

Abstract

Serum Klotho, a biomarker associated with anti-aging, has been implicated in kidney disease. However, there is a lack of robust evidence for the relationship between the serum Klotho and diabetic kidney disease (DKD). This study aimed to investigate the association of the serum Klotho levels with DKD and assess the relationship between serum Klotho and all-cause mortality in individuals with DKD.

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Research summary

The paper investigates the association between serum Klotho levels and diabetic kidney disease prevalence and mortality. The study is relevant as it explores a biomarker linked to aging and its potential implications for age-related diseases, specifically in the context of kidney health.

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