Inhibition of matrix metalloproteinase-9 attenuates kidney fibrosis and cellular senescence in the transition from acute kidney injury to chronic kidney disease.

Daoqi Shen, Liyu Lin, Yiqi Su, Jiarui Xu, Wuhua Jiang, Zhen Zhang, Yi Fang, Xiaoqiang Ding, Xialian Xu

Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China. · pubmed

Paper

Abstract

The mechanisms underlying the progression of chronic kidney disease (CKD) following acute kidney injury (AKI) remain poorly understood. Senescent cells induce maladaptive repair have been identified as a significant contributor to CKD subsequent to AKI.

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Research summary

Inhibition of matrix metalloproteinase-9 can reduce kidney fibrosis and cellular senescence in the transition from acute kidney injury to chronic kidney disease. This research addresses cellular senescence, a key factor in aging and age-related diseases, and explores mechanisms that could potentially mitigate the progression of chronic conditions associated with aging.

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