Association of hematopoietic loss of Y chromosome with valvular heart disease incidence and sex susceptibility.

Chenxuan Zhao, Yuanfeng Huang, Tianqi Ma, Xunjie Cheng, Jinchen Li, Guogang Zhang, Yongping Bai, Yu Tan

Department of Cardiovascular Medicine, Center of Coronary Circulation, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, China.Department of Cardiovascular Medicine, Center of Coronary Circulation, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, China. · pubmed

Paper

Abstract

Hematopoietic mosaic Loss Of Y chromosome (LOY), a condition referring to the age-related loss of Y chromosome in a subset of blood cells, is associated with shortened life expectancy and increased risk of age-related diseases in men. Despite Valvular Heart Disease (VHD) becoming more prevalent with aging, the underlying risk factors and mechanisms leading to sex-related differences in VHD remain unclear.

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Research summary

The paper claims that hematopoietic loss of Y chromosome is associated with increased incidence of valvular heart disease and sex susceptibility. This research explores a potential underlying mechanism related to aging and its impact on a specific age-related disease, contributing to the understanding of longevity and age-related health disparities.

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