Vitamin D promotes wound healing in aged skin by modulating inflammation, angiogenesis, and EMT via the Hippo pathway.

Yiting Gong, Yurong Ren, Ning Jia, Xiaoming Zhang, Ye Li, Xueyuan Zhi

Department of Occupational and Environmental Health, School of Public Health, Suzhou Medical College of Soochow University, 199 Renai Road, Suzhou 215123, China.Department of Occupational and Environmental Health, School of Public Health, Suzhou Medical College of Soochow University, 199 Renai Road, Suzhou 215123, China. · pubmed

Paper

Abstract

Age-related impairment in skin wound healing represents a significant healthcare challenge. Vitamin D (VD) has been shown to enhance diabetic wound healing. However, its therapeutic potential in age-related wound healing deficits remains unexplored. Here, we investigated VD's impact on wound healing in aged mice and the underlying mechanisms. Twelve-month-old C57BL/6 J mice received VD supplementation for 3 months before full-thickness excisional wounds were created. Wound healing was evaluated through multiple aspects, including inflammation, angiogenesis, epithelial-mesenchymal transition (EMT), and the Hippo signaling pathway. We also examined responses to 1α,25(OH)

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Research summary

Vitamin D supplementation enhances wound healing in aged skin by modulating inflammation, angiogenesis, and EMT through the Hippo pathway. The study addresses a significant aspect of age-related decline in healing processes, which is a critical factor in longevity and healthy aging.

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