Alcohol, Anti-HIV Drugs, and/or Hippuric Acid Deteriorate Cellular Stresses in Senescent Hepatocytes and Aging Murine Liver.

L Chen, M Kaypaghian, E Duran, C Ji

Department of Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.Department of Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA. · pubmed

Paper

Abstract

Liver disease has increased recently in aging people living with HIV and substance use disorders, and little is known about injurious effects of anti-HIV drugs, alcohol and other substances on cellular stress responses in senescent hepatocytes and aging liver. In this study, senescence of two liver cell lines: HepG2 and AML-12, was induced by hydrogen peroxide (H

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Research summary

The paper investigates the detrimental effects of alcohol and anti-HIV drugs on cellular stress responses in senescent liver cells. This research is relevant as it addresses the cellular mechanisms involved in aging and liver health, which are critical for understanding age-related diseases and potential interventions.

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