The molecular impact of cigarette smoking resembles aging across tissues.

Jose Miguel Ramirez, Rogério Ribeiro, Oleksandra Soldatkina, Athos Moraes, Raquel García-Pérez, Winona Oliveros, Pedro G Ferreira, Marta Melé

Department of Life Sciences, Barcelona Supercomputing Center (BSC), C/Jordi Girona 31, Barcelona, 08034, Spain.Department of Life Sciences, Barcelona Supercomputing Center (BSC), C/Jordi Girona 31, Barcelona, 08034, Spain. · pubmed

Paper

Abstract

Tobacco smoke is the main cause of preventable mortality worldwide. Smoking increases the risk of developing many diseases and has been proposed as an aging accelerator. Yet, the molecular mechanisms driving smoking-related health decline and aging acceleration in most tissues remain unexplored.

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Research summary

Cigarette smoking accelerates aging-related molecular changes across various tissues. The paper explores the molecular mechanisms linking smoking to aging, which is directly relevant to understanding the root causes of aging and age-related diseases.

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