Creatine and cellular senescence: from molecular pathways to populational health.

Sergej M Ostojic, Viktória Prémusz, Pongrác Ács

Faculty of Health Sciences, University of Pecs, Pecs, Hungary; Department of Nutrition and Public Health, University of Agder, Kristiansand, Norway. Electronic address: [email protected] of Health Sciences, University of Pecs, Pecs, Hungary; Department of Nutrition and Public Health, University of Agder, Kristiansand, Norway. Electronic address: [email protected]. · pubmed

Paper

Abstract

Emerging evidence suggests that creatine, a naturally occurring amino acid derivative and conditionally essential nutrient, may modulate cellular senescence through mechanisms such as enhancing cellular energy homeostasis, mitigating oxidative stress, and influencing key signaling pathways implicated in aging processes. This review critically evaluates the current body of research, highlights existing gaps in the mechanistic understanding, and emphasizes the importance of targeted studies to further delineate creatine's role in cellular senescence and age-associated dysfunctions. By integrating perspectives from molecular biology, gerontology, and applied physiology, this paper aims to advance the understanding of creatine-based strategies as potential interventions for promoting healthy aging and preventing senescence-associated conditions.

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Research summary

Creatine may modulate cellular senescence through enhancing energy homeostasis and mitigating oxidative stress. The paper addresses mechanisms related to aging and cellular senescence, which are central to understanding and potentially intervening in the aging process.

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