Balancing hematopoietic stem cell self-renewal and differentiation activities throughout ontogeny and aging.

Masayuki Yamashita, Jingjing Li, Vu L Tran, Myriam L R Haltalli, Shannon McKinney-Freeman, Toshio Suda

Division of Experimental Hematology, Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN. Electronic address: [email protected] of Experimental Hematology, Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN. Electronic address: [email protected]. · pubmed

Paper

Abstract

During fetal development, lifelong hematopoietic stem cells (HSCs) emerge from hemogenic endothelium as a part of the intra-arterial hematopoietic clusters. These definitive HSCs are deemed to colonize and expand in the fetal liver, migrate to the bone marrow, and produce mature blood cells throughout life. However, emerging lines of evidence have challenged this paradigm, and alternative models have been proposed. Moreover, recent studies have revealed expansion of HSCs during aging, which seems counterintuitive to their age-dependent reduction in regenerative capacity. Here, we summarize emerging views on hematopoietic ontogeny and aging, which was the focus of the Summer 2024 International Society for Experimental Hematology (ISEH) webinar.

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Research summary

The paper discusses the balance of hematopoietic stem cell self-renewal and differentiation throughout aging. This research is relevant as it explores fundamental mechanisms of stem cell behavior that could influence aging and regenerative capacity, potentially addressing root causes of age-related decline.

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