Late-Life Short-Term Dietary Restriction Improves Intestinal Stem Cell Function and Alters Intestinal Stem Cell Deoxyribonucleic Acid Methylation in Mice.

Kavitha Kurup, Michael Chan, Eric Moore, Michelle Ranjo-Bishop, Kevin Pham, David R Stanford, Willard M Freeman, Archana Unnikrishnan

Department of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.Department of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States. · pubmed

Paper

Abstract

Intestinal regenerative capacity declines with age due to the declining intestinal stem cell (ISC) function. Dietary restriction (DR), the most robust anti-aging intervention to date, has been shown to improve ISC function in young mice.

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Research summary

Late-life short-term dietary restriction improves intestinal stem cell function and alters their DNA methylation in mice. This research addresses the decline in regenerative capacity associated with aging, focusing on dietary interventions that may enhance stem cell function, which is directly related to longevity and age-related decline.

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