Cumulative stress and epigenetic aging: Examining the role of psychological moderators.

Seung Eun Cha, Jieun Song, Steve Cole, Carol D Ryff

Department of Psychology, University of Wisconsin-Madison.Department of Psychology, University of Wisconsin-Madison. · pubmed

Paper

Abstract

Cellular epigenetic aging has become an important marker of healthy or unhealthy aging. The current study examined whether lifelong cumulative stressors across multiple domains were linked with epigenetic age acceleration (EAA; i.e., epigenetic age greater than chronological age) and whether psychological factors moderated this association. Dimensions of psychological well-being were hypothesized as protective factors, while neuroticism was posited as a vulnerability factor.

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Research summary

Lifelong cumulative stressors are linked with epigenetic age acceleration, moderated by psychological factors. The study addresses the relationship between stress and epigenetic aging, which is crucial for understanding the biological mechanisms of aging and potential interventions for longevity.

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