Collagen Remodeling Increases After Acute Resistance Exercise in Healthy Skeletal Muscle Irrespective of Age.

Allyson M Schweitzer, Michael S Koehle, Matthew D Fliss, Cameron J Mitchell

School of Kinesiology, University of British Columbia, Vancouver, British Columbia, Canada.School of Kinesiology, University of British Columbia, Vancouver, British Columbia, Canada. · pubmed

Paper

Abstract

Alterations to the extracellular matrix of skeletal muscle are implicated in age-related declines in muscle quality. Reduced collagen breakdown and collagen accumulation between muscle fibres are suggested to reduce the force-generating capacity of the muscle and impede adaptation to mechanical loading. The current study investigated total intramuscular collagen content in healthy, physical fitness-matched young and older skeletal muscle and how regulators of collagen breakdown respond to an acute bout of resistance exercise. No differences in intramuscular collagen content between young (5.4% ± 2.1) and older muscle (5.1% ± 3.1, p=0.779) were found. Seventy-two hours after resistance exercise, matrix metalloproteinase (MMP) and tissue inhibitors of metalloproteinase (TIMP) gene expression (

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Research summary

The study claims that acute resistance exercise does not alter intramuscular collagen content in young versus older individuals. This research is relevant as it explores the relationship between exercise, collagen remodeling, and muscle quality, which are important factors in understanding and potentially mitigating age-related declines in muscle function.

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