Dehydroepiandrosterone sulfate on lifespan in men and women using Mendelian randomization.

C Mary Schooling, Jie V Zhao

City University of New York, Graduate School of Public Health and Health Policy, New York, NY, USA; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China. Electronic address: [email protected] University of New York, Graduate School of Public Health and Health Policy, New York, NY, USA; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China. Electronic address: [email protected]. · pubmed

Paper

Abstract

Dehydroepiandrosterone (DHEA) and DHEA-sulfate (-s) fall with age and are implicated in aging. Observational studies suggest DHEA/DHEA-s could lengthen life in specifically older men. No trial has established the role of DHEA/DHEA-s in aging or lifespan. We assessed the role of DHEA-s in lifespan and key biological determinants, (blood pressure, Apolipoprotein B (ApoB), and haemoglobin A1C (HbA1c)), for men and women in a two-sample mendelian randomization (MR) study using naturally occurring genetic randomization to obviate confounding.

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Research summary

The paper claims that DHEA-s influences lifespan in men and women through genetic randomization. The study addresses a potential biological determinant of aging, which is relevant to understanding lifespan extension.

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