Epigenetic age acceleration mediates the association between low-grade systemic inflammation and cardiovascular diseases: insight from the NHANES 1999-2002.

Xiaolang Chen, Jin Zhong, Yingnan Lv, Lancheng Wei, Huijiao Zhou, Yongmei Yang, Jinfan Chi, Zhen Lee, Huabei Wu, Haiying Zhang

Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, No. 22, Shuangyong Road, Nanning, 530021, Guangxi, China. · pubmed

Paper

Abstract

Currently, with the global aging of the population, inflammation, recognized as a hallmark in age-related diseases, has been studied and linked to cardiovascular diseases (CVD). However, limited evidence on whether inflammation modifies epigenetic aging and affects CVD risk.

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Research summary

Epigenetic age acceleration is influenced by low-grade systemic inflammation, which in turn affects cardiovascular disease risk. This paper is relevant as it explores the relationship between inflammation and epigenetic aging, contributing to our understanding of mechanisms that may underlie age-related diseases.

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