Ergothioneine regulates the paracrine of dermal papilla cells through SIRT1/Nrf2 pathway to antagonize oxidative stress and natural hair follicle aging.

Hailin Wang, Yueying Wang, Xin Li, Jiayang Ma, Zhiqi Hu, Qian Qu, Yong Miao

Department of Plastic and Aesthetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China. · pubmed

Paper

Abstract

Hair graying and loss are significant indicators of aging, and oxidative stress plays an essential role in this progression. Ergothioneine (EGT), potent antioxidant from edible fungi and certain prokaryotes, regulates the antioxidant defense system. However, its anti-aging effects on hair follicles (HFs) remain obscure. We used dermal papilla cells (DPCs) co-culture system, HFs organ culture system, aged mice and H

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Ergothioneine regulates the paracrine signaling of dermal papilla cells to mitigate oxidative stress and counteract hair follicle aging. The study addresses oxidative stress, a key factor in the aging process, and explores a potential intervention that could influence longevity through hair follicle health.

Author of this paper? Send a correction.