Development of a multimorbidity health conditions outcome index for caloric restriction interventional studies in older adults: a preliminary investigation in an observational cohort study.

Michael E Miller, Haiying Chen, Mark A Espeland, Fang-Chi Hsu, Denise K Houston, Anne B Newman, W Jack Rejeski, Barbara J Nicklas, Stephen B Kritchevsky

Wake Forest University School of Medicine, Winston Salem, NC, USA. [email protected]. · pubmed

Paper

Abstract

Using multiple sources, we provide the conceptual justification and statistical support for a multimorbidity outcome associated with obesity-related conditions, which we term the Health Conditions Index (HCI). This index was designed to capture the health effects of multi-year studies of caloric restriction for older adults with BMIs in the overweight or obesity classification. We used a subset of participants in the Health, Aging and Body Composition Cohort Study to evaluate multiple aspects of the index and its components over 5 years of follow-up. The 937 participants in the subset had an average age of 73 years and a BMI of 30.7 kg/m

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Research summary

The paper proposes a Health Conditions Index (HCI) to evaluate the health effects of caloric restriction in older adults with obesity. This research is relevant as it addresses the impact of caloric restriction, a potential intervention for extending healthspan and addressing age-related diseases.

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