The memory- and cognition-facilitating effects of spermidine in aging and aging-related disorders.

Mengjie Zou, Dan Li, Yi Yang

School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China; Hangzhou Key Laboratory of Medical Neurobiology, Hangzhou Normal University, Hangzhou 311121, China.School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China; Hangzhou Key Laboratory of Medical Neurobiology, Hangzhou Normal University, Hangzhou 311121, China. · pubmed

Paper

Abstract

Spermidine is a natural polyamine found in living organisms. In human, the level of spermidine declines with aging. Emerging lines of evidence indicates that supplementation of spermidine favors the improvement of memory performance and cognition function. In this article, recent findings regarding the metabolism of spermidine under pathophysiological conditions are discussed. This review emphasizes the recent mechanistic insights into the memory- and cognition-facilitating effects of spermidine, specifically detailing autophagy induction, mitochondrial protection, synaptic maintenance and other aspects. Recent advances in understanding the precise role of spermidine may shed light on the prevention and treatment of aging-associated memory and cognitive decline.

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Research summary

Spermidine supplementation may improve memory performance and cognitive function in aging individuals. The paper discusses mechanisms that could address cognitive decline, which is a significant aspect of aging and longevity research.

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