The Combination of Two Small Molecules Improves Neurological Parameters and Extends the Lifespan of C3H Strain Female Mice.

Maria Vedunova, Olga Borysova, Elena Mitroshina, Ivan Morgunov, Alexander Fedintsev, Alexey Moskalev

National Research Lobachevsky State University of Nizhniy Novgorod, (Lobachevsky University), Nizhny Novgorod, Russia.National Research Lobachevsky State University of Nizhniy Novgorod, (Lobachevsky University), Nizhny Novgorod, Russia. · pubmed

Paper

Abstract

Targeting partial cellular reprogramming pathways through specific small molecule combinations holds promise for lifespan extension in model organisms. Chemical cocktails like RepSox and tranylcypromine (TCP) may induce beneficial age-related changes without the risks of full reprogramming. This study investigated the effects of RepSox and TCP on neurological markers, physical activity, skeletal health, and survival in aging C3H female mice.

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Research summary

The combination of RepSox and tranylcypromine improves neurological parameters and extends lifespan in aging C3H female mice. This study addresses mechanisms related to lifespan extension and age-related changes, making it relevant to the field of longevity research.

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