Mitochondria transfer from mesenchymal stem cells into osteoarthritic chondrocytes ameliorate cellular functions and alleviate both inflammation and oxidative stress.

Candan Altuntaş, Gökhan Duruksu, Fatih Hunç, Yusufhan Yazir

Department of Stem Cell, Institute of Health Sciences, Kocaeli University, Izmit, Kocaeli, Turkey.Department of Stem Cell, Institute of Health Sciences, Kocaeli University, Izmit, Kocaeli, Turkey. · pubmed

Paper

Abstract

Osteoarthritis, a common age-related joint disease, causes cartilage degeneration, leading to pain and disability. While pain management exists, cartilage regeneration options are limited. Exogenous mitochondria transfer is a novel regenerative approach. This study aimed to investigate the effects of exogenous mitochondrial transfer on cellular function, oxidative stress, inflammation, and apoptosis in osteoarthritic chondrocytes.

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Research summary

Exogenous mitochondrial transfer from mesenchymal stem cells improves cellular functions in osteoarthritic chondrocytes. The study addresses a potential regenerative approach to mitigate age-related cartilage degeneration, which is a significant aspect of longevity research.

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