IDO1 improves postischemic neovascularization in aged mice by boosting endothelial NAD

Minghong Chen, Junyu Chen, Yu Liu, Jing Chen, Meilian Yao, Xuerui Wang, Jian Zhang, Miao Pan, Jipeng Zhou, Yongping Bai

Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China; Center of Coronary Circulation, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China; Center of Coronary Circulation, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China. · pubmed

Paper

Abstract

Peripheral arterial disease (PAD) is prevalent among the elderly, and therapeutic neovascularization is a research hotspot in PAD treatment. Supplementing nicotinamide adenine dinucleotide (NAD

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that IDO1 enhances postischemic neovascularization in aged mice by increasing endothelial NAD levels. This research is relevant as it explores mechanisms that could potentially address age-related vascular issues, contributing to the understanding of neovascularization in the context of aging.

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