Changes in metabolism-related RNA expression in circulating white blood cells of aged individual with physical frailty.

Yuka Okinaka, Yoshihito Suda, Tomoyuki Matsumoto, Ryosuke Kuroda, Yoshiyuki Shinagawa, Sheraz Gul, Carsten Claussen, Ikuko Matsui, Yutaka Matsui, Akihiko Taguchi

Department of Regenerative Medicine Research, Foundation for Biomedical Research and Innovation at Kobe, Kobe, Hyogo 650-0047, Japan.Department of Regenerative Medicine Research, Foundation for Biomedical Research and Innovation at Kobe, Kobe, Hyogo 650-0047, Japan. · pubmed

Paper

Abstract

Physical frailty is an age-related clinical condition associated with deterioration of physiological capacity. In aged mice, increased RNA expression of metabolism-related genes in circulating white blood cells (WBC) correlates with impaired physical function.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that increased RNA expression of metabolism-related genes in circulating white blood cells correlates with impaired physical function in aged mice. This research is relevant as it explores the metabolic changes associated with physical frailty in aging, which could provide insights into the underlying mechanisms of aging and potential interventions.

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