GDF11 Alleviates Vascular Calcification in VitD

Jiali Huang, Qingchun Liang, Yuanzhi Ye, Zirong Lan, An Chen, Jianyun Yan, Lihe Lu

Department of Pathophysiology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, People's Republic of China. · pubmed

Paper

Abstract

Vascular calcification, an age-associated disorder, is a highly regulated biological process similar to bone formation. Growth differentiation factor 11 (GDF11), a secreted member of the transforming growth factor beta (TGF-β) superfamily, has been shown to act as an anti-aging factor in the brain, heart, skin, and skeletal muscle. Nevertheless, whether GDF11 affects vascular calcification and the underlying mechanisms remain unclear. In the present study, beta-glycerophosphate and calcium chloride-induced calcification of vascular smooth muscle cells (VSMCs) and a VitD

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Research summary

GDF11 alleviates vascular calcification in vascular smooth muscle cells. The study addresses a biological process associated with aging and explores a potential mechanism that could influence age-related vascular health.

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