Restoring calcium crosstalk between ER and mitochondria promotes intestinal stem cell rejuvenation through autophagy in aged Drosophila.

Yao Zhang, Peng Ma, Saifei Wang, Shuxin Chen, Hansong Deng

Yangzhi Rehabilitation Hospital, Sunshine Rehabilitation Center, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 20092, China.Yangzhi Rehabilitation Hospital, Sunshine Rehabilitation Center, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 20092, China. · pubmed

Paper

Abstract

Breakdown of calcium network is closely associated with cellular aging. Previously, we found that cytosolic calcium (CytoCa

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Research summary

Restoring calcium crosstalk between the endoplasmic reticulum and mitochondria rejuvenates intestinal stem cells through autophagy in aged Drosophila. This research addresses a fundamental aspect of cellular aging by exploring mechanisms that could potentially reverse age-related decline in stem cell function.

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