Upregulation of SIRT1 ameliorates apoptosis of rat nucleus pulposus cells under oxidative stress through FoxO1/β-catenin pathway.
Abstract
Age-related degenerative changes in intervertebral discs (IVDs) can lead to lower back pain, and even paralysis. This topic is therefore garnering growing attention in an increasingly ageing society. The oxidative stress-induced degenerative process is a major contributor to apoptosis in nucleus pulposus cells. However, the regulatory mechanism of NAD-dependent protein deacetylase Sirtuin-1 (SIRT1) on apoptosis in oxidative stress-induced rat nucleus pulposus cells remains unclear.
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Research summary
The paper claims that upregulation of SIRT1 can reduce apoptosis in rat nucleus pulposus cells under oxidative stress through the FoxO1/β-catenin pathway. This research is relevant as it explores a potential mechanism to mitigate age-related degeneration in intervertebral discs, addressing a root cause of aging-related issues such as lower back pain.
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