The Effect of Blue Light on Mitochondria in Human Dermal Fibroblasts and the Potential Aging Implications.

Helen McNish, Mruthyunjaya Swamy Mathapathi, Katarzyna Figlak, Anita Damodaran, Mark A Birch-Machin

Dermatological Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK. · pubmed

Paper

Abstract

The deleterious effects of blue light on the skin are becoming an increasing area of research focus, as we are exposed to increasing amounts of blue light in our daily lives. However, the effects of blue light on mitochondrial DNA (mtDNA) damage, mitochondrial function, and production of reactive oxygen species (ROS) have yet to be investigated. Our study involved exposing neonatal human dermal fibroblasts (HDFn) to varying doses of blue light and analyzing mtDNA damage using qPCR, mitochondrial function using a Seahorse XF bioanalyzer, and ROS production using a ROS-Glo assay. Blue light induces increased mtDNA damage dose dependently, with 50 J/cm

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Research summary

Blue light exposure induces dose-dependent mitochondrial DNA damage in human dermal fibroblasts. The study addresses the impact of environmental factors on mitochondrial function, which is a key aspect of aging and longevity research.

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