Acetylation profiling by Iseq-Kac reveals insights into HSC aging and lineage decision.

Yanqiu Gong, Huiwen Zhan, Ni Wei, Min Liu, Yu Liu, Pengbo Guan, Yusi Xie, Yujun Deng, Qianlun Pu, Xiaoxian Lou, Xiaodong Wang, Rou Zhang, Ping Wang, Xiuxiu Jin, Xiuxuan Wang, Zhiqiang Xu, Li Gao, Xinyuan Wang, Siyu He, Ying Lu, Meng Hu, Wanmeng Li, Kun Zheng, Yong Peng, Peng Lei, Heng Xu, Yujun Shi, Jun Qin, Hongbo Hu, Huiyuan Zhang, Lunzhi Dai

Center for Hematology and Immunology and National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.Center for Hematology and Immunology and National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China. · pubmed

Paper

Abstract

Profiling post-translational modifications face challenges with low-input samples. We developed Iseq-Kac (internal standard-assisted enrichment-free approach for high-throughput quantitative analysis of lysine acetylation) to profile the acetylome in as few as 10

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Research summary

The paper claims to provide insights into the acetylome of hematopoietic stem cells (HSCs) and their aging and lineage decisions. This research is relevant as it explores the molecular mechanisms underlying HSC aging, which is a fundamental aspect of the aging process and could inform strategies for longevity and age-related interventions.

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