Therapeutic potential of young plasma in reversing age-related liver inflammation via modulation of NLRP3 inflammasome and necroptosis.

Burcu Baba, Taha Ceylani, Hikmet Taner Teker, Seda Keskin, Aysun Inan Genc, Rafig Gurbanov, Eda Acikgoz

Department of Medical Biochemistry, Faculty of Medicine, Yuksek Ihtisas University, Ankara, Turkey.Department of Medical Biochemistry, Faculty of Medicine, Yuksek Ihtisas University, Ankara, Turkey. · pubmed

Paper

Abstract

The phenomenon of inflammaging, characterized by an increase in low-grade chronic inflammation, is closely associated with diseases related to liver dysfunction. This study investigated daily plasma exchange between 5-week-old and 24-month-old Sprague Dawley rats for 30 days, focusing on protein secondary structures, NLRP3 inflammasome, and necroptosis. Conformation changes in protein secondary structures were identified by infrared spectroscopy-based pattern recognition analysis. Liver biopsies with histochemical and immunohistochemical staining were used to assess molecules associated with inflammation, necroptosis and NLRP3 inflammasome complex. Expression levels of NLRP3 components were determined by qPCR. Enhanced random coils, 3

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Research summary

The paper claims that young plasma can reverse age-related liver inflammation by modulating the NLRP3 inflammasome and necroptosis. This research addresses mechanisms of aging and inflammation, which are central to longevity studies.

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