Age- and sex-specific deterioration on bone and osteocyte lacuno-canalicular network in a mouse model of premature aging.

Dilara Yılmaz, Francisco C Marques, Lorena Gregorio, Jérôme Schlatter, Christian Gehre, Thurgadevi Pararajasingam, Wanwan Qiu, Neashan Mathavan, Xiao-Hua Qin, Esther Wehrle, Gisela A Kuhn, Ralph Müller

Institute for Biomechanics, ETH Zurich, Zurich, Switzerland. · pubmed

Paper

Abstract

Age-related osteoporosis poses a significant challenge in musculoskeletal health; a condition characterized by reduced bone density and increased fracture susceptibility in older individuals necessitates a better understanding of underlying molecular and cellular mechanisms. Emerging evidence suggests that osteocytes are the pivotal orchestrators of bone remodeling and represent novel therapeutic targets for age-related bone loss. Our study uses the prematurely aged Polg

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Research summary

The study investigates the deterioration of bone and osteocyte networks in a mouse model of premature aging. This research is relevant as it addresses the cellular mechanisms underlying age-related osteoporosis, which is a significant aspect of aging and longevity.

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