Semiconducting polymer dot-based wireless electrochemical aptasensor for detection of aging-related TGF-β1 and IL-6.

Akhmad Irhas Robby, Songling Jiang, Eun-Jung Jin, Sung Young Park

Chemical Industry Institute, Korea National University of Transportation, Chungju, 27469, Republic of Korea; Department of Chemical & Biological Engineering, Korea National University of Transportation, Chungju, 27469, Republic of Korea.Chemical Industry Institute, Korea National University of Transportation, Chungju, 27469, Republic of Korea; Department of Chemical & Biological Engineering, Korea National University of Transportation, Chungju, 27469, Republic of Korea. · pubmed

Paper

Abstract

The senescence-associated secretory phenotype (SASP) is closely linked to aging by promoting inflammation and tissue degradation. Sensing SASP is crucial for early detection of and intervention in age-related diseases to enhance therapeutic outcomes. Herein, SASP-selective sensors (transforming growth factor [TGF]-β1 and interleukin [IL]-6 probes) were designed by utilizing TGF-β1/IL-6 aptamers-functionalized copper-immobilized polymer dots that promoted specific binding between TGF-β1/IL-6 aptamers on the probe surface with aging factors (TGF-β1 and IL-6).

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Research summary

The paper presents a novel sensor for detecting aging-related inflammatory markers TGF-β1 and IL-6. This research is relevant as it addresses the senescence-associated secretory phenotype (SASP), which is linked to the underlying mechanisms of aging and age-related diseases.

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