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RESEARCH PAPER / 2025-05-23

CCN Proteins as Matricellular Regulators of Bone in Aging and Disease.

Parveez Ahamed Abdul-Azees, Rahul Rajesh, Travis J Block, David D Dean, Chih-Ko Yeh, Maegan Capitano, Melissa Kacena, Xiao-Dong Chen, Miloš Marinković

Department of Comprehensive Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229 - 3900, USA.Department of Comprehensive Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229 - 3900, USA. · pubmed

Abstract

This review explores the role of cell communication network (CCN) proteins in regulating skeletal physiology, aging, and disease, particularly within the context of balanced bone remodeling.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

CCN proteins play a role in regulating bone remodeling, which is crucial for understanding aging and age-related diseases. The paper is relevant as it addresses the biological mechanisms involved in skeletal physiology and aging, potentially contributing to insights on longevity and age-related conditions.

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