Microglia activation orchestrates CXCL10-mediated CD8

Janos Groh, Ruoqing Feng, Xidi Yuan, Lu Liu, Dennis Klein, Gladis Hutahaean, Elisabeth Butz, Zhen Wang, Lisa Steinbrecher, Jonas Neher, Rudolf Martini, Mikael Simons

Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany. [email protected]. · pubmed

Paper

Abstract

Aging is the major risk factor for neurodegeneration and is associated with structural and functional alterations in white matter. Myelin is particularly vulnerable to aging, resulting in white matter-associated microglia activation. Here we used pharmacological and genetic approaches to investigate microglial functions related to aging-associated changes in myelinated axons of mice. Our results reveal that maladaptive microglia activation promotes the accumulation of harmful CD8

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Research summary

Maladaptive microglia activation promotes the accumulation of harmful CD8 T cells in aging-associated changes in myelinated axons. The study addresses the role of microglia in aging and neurodegeneration, which is pertinent to understanding the underlying mechanisms of aging and potential interventions.

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