Anti-Senescence Effect of Inhibiting Sodium-Glucose Cotransporter 2 and α-Glucosidase in a Type 2 Diabetes Mellitus Animal Model.

Serin Hong, Byung Soo Kong, Hyunsuk Lee, Young Min Cho

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. · pubmed

Paper

Abstract

The prevalence of type 2 diabetes mellitus (T2DM) increases with age, and cellular senescence of pancreatic β-cells plays a key role in T2DM pathogenesis. As canagliflozin and acarbose have been shown to increase lifespan in mice, we investigated the effect of sodium-glucose cotransporter 2 (SGLT2) inhibitor, α-glucosidase inhibitor or both on the cellular senescence of β-cells in a T2DM mouse model.

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Research summary

Inhibiting SGLT2 and α-glucosidase can reduce cellular senescence in pancreatic β-cells in a T2DM mouse model. The paper is relevant as it explores potential interventions that target cellular senescence, a key aspect of aging, in the context of a disease that is prevalent in older populations.

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