Roles of Brd4 in Vascular Smooth Muscle Cells: Implications for Aging and Vascular Dysfunction.

Jiaxing Sun, Yu Gui, Hao Yin, Binjie Yan, Yongxiang Chen, Darrell Belke, Joseph A Hill, Shenghua Zhou, Xi-Long Zheng

Department of Biochemistry and Molecular Biology and Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Alberta, Canada. (J.S., Y.G., B.Y., X.-L.Z.). · pubmed

Paper

Abstract

Growing evidence suggests that the epigenetic reader Brd4 (bromodomain-containing protein 4) is involved in aging and aging-related diseases. However, the specific mechanisms by which Brd4 influences vascular aging, especially senescence of vascular smooth muscle cells (SMCs), remain unexplored.

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Research summary

The paper investigates the role of Brd4 in vascular smooth muscle cell senescence, which may contribute to understanding the mechanisms of vascular aging. This research is relevant as it explores potential underlying mechanisms of aging rather than merely addressing symptoms of age-related diseases.

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