Physical Activity Modifies the Metabolic Profile of CD4

Jon Hazeldine, Edward Withnall, Alba Llibre, Niharika A Duggal, Janet M Lord, Amanda V Sardeli

Department of Inflammation and Aging, University of Birmingham, Birmingham, UK.Department of Inflammation and Aging, University of Birmingham, Birmingham, UK. · pubmed

Paper

Abstract

T-cell metabolism is a key regulator of immune function. Metabolic dysfunction in T cells from young mice results in an aged phenotype, accelerating immunosenescence. Physical activity (PA) maintains T-cell function and delays immunosenescence in older adults, but the underlying mechanisms are poorly understood. We investigated the effects of PA on the metabolic and functional profiles at a single-cell resolution of resting and stimulated T cells from young adults (N = 9, 23 ± 3 years) and physically active older adults clustered between higher PA (HPA, N = 9, 75.5 ± 4.7 years) or lower PA levels (LPA, N = 10, 76.4 ± 2.1 years). Compared to young donors, HPA older adults had higher mitochondrial dependence (MD) and lower glucose dependence (GD) in unstimulated naïve, central memory (CM) and effector memory (EM) CD4

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Research summary

Physical activity modifies the metabolic profile of CD4 T cells, enhancing mitochondrial dependence and reducing glucose dependence in older adults. This research addresses the mechanisms by which physical activity can influence immune function and potentially delay immunosenescence, which is directly related to aging and longevity.

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