Clonal tracing with somatic epimutations reveals dynamics of blood ageing.

Michael Scherer, Indranil Singh, Martina Maria Braun, Chelsea Szu-Tu, Pedro Sanchez Sanchez, Dominik Lindenhofer, Niels Asger Jakobsen, Verena Körber, Michael Kardorff, Lena Nitsch, Pauline Kautz, Julia Rühle, Agostina Bianchi, Luca Cozzuto, Robert Frömel, Sergi Beneyto-Calabuig, Caleb Lareau, Ansuman T Satpathy, Renée Beekman, Lars M Steinmetz, Simon Raffel, Leif S Ludwig, Paresh Vyas, Alejo Rodriguez-Fraticelli, Lars Velten

Computational Biology and Health Genomics, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Barcelona, Spain. · pubmed

Paper

Abstract

Current approaches used to track stem cell clones through differentiation require genetic engineering

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Research summary

The paper claims that clonal tracing with somatic epimutations can reveal the dynamics of blood aging. This research is relevant as it explores the mechanisms of aging at the cellular level, potentially contributing to understanding the root causes of aging and how to address them.

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