Genome-Wide Association Study of Age-Related Hearing Loss in CFW Mice Identifies Multiple Genes and Loci, Including Prkag2.

Oksana Polesskaya, Ely Boussaty, Riyan Cheng, Olivia A Lamonte, Thomas Y Zhou, Eric Du, Thiago Missfeldt Sanches, Khai-Minh Nguyen, Mika Okamoto, Abraham A Palmer, Rick Friedman

Department of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA. [email protected] of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA. [email protected]. · pubmed

Paper

Abstract

Age-related hearing loss (ARHL) is one of the most prevalent conditions affecting the elderly. ARHL is influenced by a combination of environmental and genetic factors; the identification of the genes that confer risk will aid in the prevention and treatment of ARHL. The mouse and human inner ears are functionally and genetically homologous. We used Carworth Farms White (CFW) mice to study the genetic basis of ARHL because they are genetically diverse and exhibit variability in the age of onset and severity of ARHL.

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Research summary

The paper identifies multiple genes and loci associated with age-related hearing loss in mice. The study is relevant as it explores genetic factors contributing to a common age-related condition, potentially informing interventions that could mitigate aspects of aging.

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