Chronic low-level exposure to Pb, Hg, and Cd mixture triggers brain premature aging in rat.

Jie Xie, Lu Ouyang, Jiajun Li, Shuo Yang, Qi Li, Yue Li, Lingyu Yan, Yihong Fu, Qijun Li, Yuting Xia, Xinling Chen, Ziyang Fu, Weipeng Sun, Guihua Du, Fankun Zhou, Chang Feng, Guangqin Fan

Department of Occupational Health and Toxicology, School of Public Health, Jiangxi Medical College, Nanchang University, Nanchang 330006, PR China; Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, Nanchang 330006, PR China.Department of Occupational Health and Toxicology, School of Public Health, Jiangxi Medical College, Nanchang University, Nanchang 330006, PR China; Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, Nanchang 330006, PR China. · pubmed

Paper

Abstract

Lead (Pb), mercury (Hg), and cadmium (Cd), prevalent neurotoxic heavy metals in the environment, are commonly detected at low concentrations in the blood of the general population. Our previous studies demonstrated that Pb, Hg, and Cd mixture induced neurodevelopmental toxicity even at very low levels. However, the long-term effects of low-level Pb, Hg, Cd exposure on brain aging remain unclear. In this study, female rats were exposed to a mixture of 10 mg/L Pb(CH

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Research summary

Chronic low-level exposure to a mixture of lead, mercury, and cadmium accelerates brain aging in rats. The study addresses the long-term effects of environmental neurotoxicants on brain aging, which is pertinent to understanding the root causes of aging and age-related neurodegenerative processes.

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