Higher Circulating Alpha-Klotho Levels Increase All-Cause Mortality Through Mediation Effects of Liver Fibrosis: A Second Analysis of NHANES.

Kai Wei, Qing Zhang, Chun Chen, Yanping Yang, Shuimei Sun, Libin Wang, M S Xiaotong Chen, Xinhua Luo, Qi Chen

Department of Pharmacy, Guizhou Provincial People's Hospital, 83 East Zhongshan Road, Guiyang, Guizhou Province, 550002, China. · pubmed

Paper

Abstract

Laboratory studies have demonstrated that mice with α-klotho gene deficiency experience a shortened lifespan, but epidemiological evidence linking circulating α-klotho levels and mortality remain inconclusive. This study aimed to examine the association between α-klotho and mortality and to explore how liver fibrosis mediate this association.

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Research summary

Higher circulating alpha-klotho levels are associated with increased all-cause mortality mediated by liver fibrosis. This paper is relevant as it explores the relationship between a biomarker (alpha-klotho) and mortality, potentially shedding light on mechanisms underlying aging and longevity.

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