Supplementation of low-protein diets with plant protein and probiotics enhances muscle health by regulating gut microbiota and metabolomic profiles in SAMP8 mice.

Ruyi Han, Limin Ouyang, Chenggang Yin, Long Cai, Qiming Wu, Liang Chen, Jun Du, Xilong Li, Zhigang Zhu, Yu Pi

Key Laboratory of Feed Biotechnology of Ministry of Agriculture and Rural Affairs, Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing 100081, China. [email protected]. · pubmed

Paper

Abstract

Muscle health is crucial, especially for aging populations. This study investigates how plant protein and probiotic supplementation in a low-protein (LP) diet affects the gut microbiota, metabolome, and muscle health in aging SAMP8 mice, emphasizing the gut-muscle axis in older populations. Twenty-four 8-month-old male SAMP8 mice were divided into four groups: control (CON, standard diet), low-protein (LP), LP supplemented with plant protein (LP + P), and LP supplemented with plant protein and probiotics (LP + P + B). The experimental treatment lasted 8 weeks. Results showed that, by week 6, body weight increased significantly in all LP groups, with a trend toward higher body fat. Protein utilization and muscle strength improved significantly in the supplemented groups compared to the LP group (

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Supplementation of low-protein diets with plant protein and probiotics improves muscle health in aging mice by regulating gut microbiota and metabolomic profiles. This study addresses the gut-muscle axis, which is a relevant aspect of aging and muscle health, potentially contributing to understanding interventions that could mitigate age-related decline.

Author of this paper? Send a correction.