A multifunctional metformin loaded carboxymethyl chitosan/tannic acid/manganese composite hydrogel with promising capabilities for age-related bone defect repair.

Jingle Chen, Chao Xie, Yucong Li, Qili Sun, Fengnian Yu, Kai Li, Haotian Gao, Zhaoquan Liang, Bin Tang, Lijun Lin

Department of Joint and Orthopedics, , Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, PR China; Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, PR China. · pubmed

Paper

Abstract

As the global population ages, age-related bone defects have become a major public health challenge. The decline in bone tissue repair capacity among the elderly is primarily attributed to the senescence of bone marrow mesenchymal stem cells (BMSCs), which leads to reduced proliferation and differentiation capabilities, thereby impeding the bone healing process. Additionally, the deterioration of the bone microenvironment, characterized by chronic inflammation and oxidative stress, further complicates bone repair. To address these issues, a multifunctional hydrogel drug delivery system, the metformin-loaded carboxymethyl chitosan/tannic acid/manganese (MCTM) hydrogel was developed. This system integrates the synergistic effects of CMCS, TA, Mn

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Research summary

The paper claims that a multifunctional hydrogel system can enhance bone defect repair in the elderly by addressing the decline in bone tissue repair capacity. This research is relevant as it targets the underlying issues related to aging and aims to improve regenerative processes, which are crucial for longevity.

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