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RESEARCH PAPER / 2025-05-17

Anti-sarcopenic effect of leucine-enriched branched-chain amino acid supplementation among elderly chronic kidney disease patients: a double-blinded randomized controlled trial.

Neti Sunsandee, Paramat Thimachai, Bancha Satirapoj, Ouppatham Supasyndh

Division of Nephrology, Department of Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand. · pubmed

Abstract

Leucine, a branched-chain amino acid (BCAA), is an effective nutritional strategy to enhance skeletal muscle mass in aging populations. This study aimed to evaluate the effects of oral leucine-enriched BCAA supplementation on muscle mass, muscle synthesis biomarkers, and physical performance in elderly patients with chronic kidney disease (CKD).

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that leucine-enriched BCAA supplementation can enhance muscle mass and physical performance in elderly CKD patients. This research is relevant as it addresses muscle loss, a significant aspect of aging and longevity, by exploring nutritional interventions that may mitigate age-related decline in muscle mass.

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