Unveiling the impact of DNA-methylation age acceleration on mortality risk in diabetes and pre-diabetes: insights from the US NHANES program.

Shuang Wu, Ziyi Zhong, Yimeng Wang, Jingyang Wang, Siqi Lyu, Hongyu Liu, Yang Chen

National Center for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. · pubmed

Paper

Abstract

Diabetes ranks as the ninth leading cause of death globally, and DNA-methylation age acceleration (DNAmAA) is closely linked to lifespan. However, the impact of DNAmAA on long-term outcomes in specific populations with diabetes and pre-diabetes has not yet been comprehensively studied.

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Research summary

The paper investigates the relationship between DNA-methylation age acceleration and mortality risk in individuals with diabetes and pre-diabetes. This research is relevant as it explores a potential biomarker (DNAmAA) that could provide insights into aging processes and longevity in a specific population.

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