Blood transcriptomic associations of epigenetic age in adolescents.

Dennis Khodasevich, Anne K Bozack, Saher Daredia, Julianna Deardorff, Kim G Harley, Brenda Eskenazi, Weihong Guo, Nina Holland, Andres Cardenas

Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA.Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA. · pubmed

Paper

Abstract

Epigenetic aging in early life remains poorly characterized, and patterns of gene expression can provide biologically meaningful insights. Blood DNA methylation was measured using the Illumina EPICv1.0 array and RNA sequencing was performed in blood in 174 adolescent participants (age range: 14-15 years) from the CHAMACOS cohort. Thirteen widely used epigenetic clocks were calculated, and their associations with transcriptome-wide RNA expression were tested using the

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Research summary

The paper investigates the associations between epigenetic age and gene expression in adolescents. This research is relevant as it explores the biological mechanisms of aging at an early life stage, potentially contributing to our understanding of the root causes of aging.

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