Inhibition of caspase-1 by ginsenoside Rg1 ameliorates d-gal-induced renal aging and injury through suppression of oxidative stress and inflammation.

Tingting Guo, Ting Xie, Xuejun Chen, Jingying Zhong, Zhenyu Bai, Huiyu Liang, Xiaoshan Zhao, Meixia Fang, Ya Xiao, Jun Zhang

Department of Nephrology, Zhujiang Hospital of Southern Medical University, Guangzhou, China. · pubmed

Paper

Abstract

The disruption of renal cell homeostasis caused by aging has attracted considerable attention. A traditional Chinese medicine, ginseng, is a potential drug for treating aging-related diseases. The study investigates the effect and mechanism of ginsenoside Rg1, an active component of ginseng, on renal aging and injury.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that ginsenoside Rg1 inhibits caspase-1 to ameliorate renal aging and injury. This research addresses a potential mechanism related to aging and seeks to mitigate the effects of aging on renal function, which aligns with longevity research.

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