Klotho null mutation leads to retinal degeneration characterized by functional impairment, gliosis, and deposition of amyloid-beta and hyperphosphorylated tau proteins.

Zhi-Jia Chen, Chun-Yen Wu, Fang-Yan Hsiao, Jing-Chun Ma, Gabriel Lai, Han-Hsin Chang, David Pei-Cheng Lin

Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, TaiwanRepublic of China. · pubmed

Paper

Abstract

Klotho mutation has been known to accelerate aging and degenerative pathogenesis, notably in the kidney and the brain. Nevertheless, the aftermath of Klotho function deprivation in the retina has not been detailed. This study aimed to provide an in-depth analysis of retinopathy caused by Klotho mutation.

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Research summary

Klotho null mutation leads to retinal degeneration characterized by functional impairment and gliosis. The study addresses the role of Klotho in aging-related degeneration, which is pertinent to understanding the mechanisms of aging and potential interventions.

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